The mechanical engineering option is accredited by the Engineering Accreditation Commission of ABET, 111 Market Place, Suite 1050, Baltimore, MD 21202-4012, (410) 347-7700. My laboratory pioneered methods to direct the evolution of enzymes, and we continue to refine and develop new approaches to protein engineering.

California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, USA. Powered by Create your own unique website with customizable templates. PDF Supp. Our lab uses a combination of structural and functional techniques, including cryo-electron microscopy and protein biochemistry, to understand i) the molecular mechanism of protein biogenesis and ii) how proteins and mRNAs that fail at any step during this maturation process are recognized and degraded. Ph.D. Molecular Biology, University of California, Los Angeles (2021) . The focus of the lab is the coupling of theoretical, computational, and experimental techniques for the study of structural biology. 2 Howard Hughes Medical Institute, Pasadena, California 91125. Biological and Cryogenic Transmission Electron Microscopy at Caltech > Molecular Observatory for Structural Molecular Biology at Caltech > Stanford Synchrotron Radiation Facility > Advanced Light Source > Advanced Photon Source >. The archive on this site houses the previous ten years' Catalog files, with a link to the repository of all Catalog files maintained by the Caltech Library. Simons Electron Microscopy Center at the New York Structural Biology Center cryo-EM overview; What Could Go Wrong? This research sparked Dr. Sharaf's current interest in . 1 Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125; email: [email protected] , [email protected] Shu-ou Shan Executive Officer Phone: (626) 395-3879 Office: 109 Braun E-mail: [email protected] Contact. Structural Biology @ Caltech Loading. February 12, 2015. Much of our research focuses on dissecting microbial cell biology, with a particular emphasis on cellular nanomachines. Presenter: Benjamin Basanta Panelists: Mark Herzik, Jose Rodriguez and Elizabeth Villa . 1200 East . Active involvement in research, particularly during the . Steve Mayo is the Bren Professor of Biology and Chemistry at the California Institute of Technology in Pasadena, California. 2 Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, 6703 HB Wageningen, Netherlands. within the division of biology and biological engineering at caltech, computational biology questions that form the focus of current research efforts include how to model and understand the role of protein structures, how to interpret and analyze genomics data, and what are the best ways to perturb and control biological systems to reveal their Marshall, John M., and Hay, Bruce A. Minor. have the basic skills in mathematics, physics, chemistry, information science, computing, biology, engineering to address problems in their chosen discipline, be able to communicate this scientific and engineering knowledge to peers, experts, and the public, and . Current areas of study include cell plans, the cytoskeleton, subcellular compartmentalization, the mechanics of cell division, motility and . Caltech Structural Biology Group STRUCTURAL BIOLOGY at CALTECH Andre Hoelz Lab Bil Clemons Lab David Chan Lab Douglas C. Rees Lab Grant Jensen Lab Pamela J. Bjorkman Lab Stephen L. Mayo Lab Macromolecular Crystallography Lab Molecular Observatory for Structural Molecular Biology We are fundamentally biochemists who want to know how the cell works at the atomic level. Microbial Cell Biology. Facilities. 451-453. In: Molecular Biology of Neurodegenerative Diseases. The unifying theme to her work is an experimental and theoretical approach at the intersection . California Institute of Technology, Chemistry Major, First Year. A list of current faculty option representatives and their . BMC Structural Biology BMC Structural Biology 2002, 2Research article x Open Access (ILT2) in regions implicated in the binding of the Human . Now, a new technique developed at Caltech can render intact bones transparent, allowing researchers to observe these stem cells within their environment. Architects of Structural Biology is an amalgam of memoirs, biography, and intellectual history of the personalities and single-minded devotion of four scientists who are among the greatest in modern times. Bren Professor of Biology and Chemistry. Structural Mechanics; Interdisciplinary Studies Program. The physical cornerstone of the initiative was the Broad Center for the Biological Sciences, made possible by a lead gift of $18 million from The Eli and Edythe Broad Foundation. . Biochemistry & Molecular Biophysics | Division of Chemistry and Chemical Engineering Biochemistry & Molecular Biophysics Biochemistry and Molecular Biophysics has been established as an interdisciplinary program, at the interface of biology, chemistry, and physics, that seeks to understand the basic molecular mechanisms of life. A Practical Guide to Single-Particle Cryo-EM: From Biochemistry to Atomic Models - a recent review by Michael A. Cianfrocco and Elizabeth H. Kellogg; Prof. Jensen's online videos on the theory and principles of cryo-EM (14 hours) . hhmi. The undergraduate option in biology is designed to build on a solid foundation in mathematics and physical science by providing an introduction to the basic facts, concepts, problems, and methodologies of biological science. Decoding the roles of non-coding RNAs in shaping nuclear structure and gene expression. The option representative provides consultation on academic programs, degree requirements, financial aid, etc. (Diplom) Chemistry and Biochemistry, University of Freiburg, Germany (1997) . The primary goal of our team is to train a dynamic, diverse, and talented group of scientists interested in structural biology and membrane proteins. . Caltech Engineering and Applied Science faculty work at the edges of fundamental science to invent the technologies of the future. The option serves as a basis for graduate study in any field of biology or for admission to the study of medicine. California Institute of Technology. Graduate Program Bio. To determine structural correlates of SARS-CoV-2 neutralization, we solved 8 new structures of distinct COVID-19 hNAbs in complex with SARS-CoV-2 spike trimer or RBD.

Our research in the Laboratory of Structural Biology aims at understanding the structure and function of biological macromolecules and their complexes, such as those involved in cellular cargo transport, protein folding, cell-cell contacts and viral infection. Powered by Create your own unique website with customizable templates. . e-mail [email protected] Phone x1796 / Lab x1728 Address 1200 E California Blvd MC 114-96, Pasadena, CA 91125. the division of biology and biological engineering welcomes applications in all areas of biological science and biological engineering, with particular interest in exceptionally creative individuals who are interested in pursuing research in areas that benefit from the interdisciplinary environment of caltech's bbe division and its linkages to

Contact. John R. Desjarlais, Stephen L. Mayo, Editorial overview: Computational protein design, Current Opinion in Structural Biology, Volume 12, Issue 4, 1 August 2002, Pages 429-430, ISSN 0959-440X, 10.1016/S0959-440X(02)00343-3. Confinement of gene drive systems to local populations: A comparative analysis.

The Dougherty group in the Division of Chemistry and Chemical Engineering at the California Institute of Technology conducts research in organic chemistry and chemical biology. molecular and cellular biology laboratories are investigating the underlying molecular mechanisms of fundamental cellular and organismal processes including the replication, expression, and repair of the genome, transduction of signals from the cell surface to the nucleus in response to diffusible signals or cell-cell interaction, protein The Clemons group is primarily interested in understanding the molecular details of life and as a tool we focus on "structural biology". Astrid P Heikema1,2, Anthony P West Jr1 and Pamela J Bjorkman1,2 Address: 1Division of Biology 156-29 California Institute of Technology Pasadena, California 91125, USA, 2Howard Hughes Medical . The major focus of the group seeks a chemical-scale understanding of ion channels and neuroreceptors. Since 1963, the Fannie and John Hertz Foundation has awarded over 1,100 doctoral fellowships with the goal of supporting the early stage research endeavors of applied physical, biological, and engineering science students who possess the potential to change our world for the better by solving difficult, real-world problems. To expand her structural biology skill set, she undertook postdoctoral training at Caltech in the lab of Dr. Doug Rees where she characterized the structure and function of the Neisseria meningitides methionine ABC transport system using x-ray crystallography and single-particle cryo-EM.

RESEARCH TECHNICIAN

. Undergraduate Mechanical Engineering Division of Engineering and Applied Science Caltech Course Catalog. A faculty member serves as the representative for an option. Option Representatives. expression profile, to deliver personal biology-driven health interventions by connecting people to others with similar immune system profiles to share their health journeys. . Supervised by Taylor Stevens. Molecular Insights into Parkinson's Disease. HIV is unusual in that while each virus has the same basic membrane and protein layers, they are all unique, making standard methods such as X-ray crystallography or EM . We develop cutting-edge technologies based in biochemistry, cell biology, genomics and computational biology to address these questions. Dual Affiliation with Division of Biology and Biological Engineering. Explore the facilities available for use at the Rees Lab. Distinct from most of the other structural biology groups working with purified macromolecules, the Chang lab utilizes cryo-electron tomography ( cryo-ET ), a powerful cryo-electron microscopy imaging . Courtney Oaida BMB Graduate Option Manager Phone: (626) 395-6446 Office: 162 Crellin E-mail: [email protected] Bil Clemons Option Representative Phone: (626) 395-1796 Office: 157 Broad Center E-mail: [email protected] Prof. Paul Freemont's research focuses on the molecular mechanisms of human disease using the tools of integrated structural biology comprising X-ray crystallography, Cryo-EM and associated biophysical, spectroscopic and cellular techniques.In addition, Prof. Freemont is an internationally-leading synthetic biologist with active research interests in cell-free biotechnologies and global health . Xiaozhe received his BS from Tsinghua University, Bejing, China in 2014. Structural Biology @ Caltech Loading. We can't do everything.yet, so we currently work on problems related to protein transport across membranes and post-translational modification of proteins. . This minor is intended to supplement one of Caltech's undergraduate degrees and is designed for students who wish to broaden their knowledge beyond their normal major, especially for those who wish to join the structural engineering profession after graduation or pursue a graduate degree in structural mechanics or structural engineering. Before joining Caltech, he was involved in multiple projects on structural biology and protein engineering. Shinae Park, B.S. California Institute of Technology. In the Gradinaru Lab, Xiaozhe is working on developing new molecular tools and viral vectors for neuroscience.

and provides general supervision to undergraduate and/or graduate students in the option. To date we have imaged nearly 100 microbial species by cryoET. Karen Orta (Caltech) Structural insights behind phage single-gene lysis protein E 1:25 - 1:40 Maria Flores (UCLA) CryoEM structure of human CPEB3's reversible prion-like domain . e-mail [email protected] Phone x1796 / Lab x1728 Address 1200 E California Blvd MC 114-96, Pasadena, CA 91125. Plckthun, Andreas and Mayo, Stephen L. (2007) The design of evolution and the evolution of design. Here at Caltech, we have access to leaders in several keystone areas of biology, including professors Rebecca Voorhees (co-author on the published manuscript), Bil Clemons, and Shu-ou Shan in structural biology, all of whom were willing to discuss ramifications of our data and provide expertise in this relatively new area for us." application of the methods and concepts of mathematics, physics, chemistry, engineering, and information science are providing deep insight into classical biological problems such as the nature of heredity, the control of protein function, the regulation of gene expression in cells, the regulation of cellular activity, the mechanisms of growth In 2021, she joined the Gradinaru lab and is excited to serve as project manager for the Aligning Science Across Parkinson's team. In particular, we have placed a major emphasis on developing quantitative methods for protein design with the goal of developing a fully systematic design strategy that we call "protein design automation." Access to over 40,000 titles, books, and videos across areas including programming, data analysis, math, science, engineering, business, arts, psychology, economics, political science, history, and more. Caltech laboratories are using structural biology, molecular biology, and mouse genetics to study how the immune system develops, how the immune system interacts with microbes that naturally reside in our bodies and are not pathogens, and how signals are transduced in both the innate and adaptive branches of the immune system. Ph.D. Before joining Caltech, he was involved in multiple projects on structural biology and protein engineering. People Prof. Bil Clemons (CV March 2021) Arthur and Marian Hanisch Memorial Professor of Biochemistry Post Doc, Harvard Medical School (2001-2005) .

Journal of Theoretical Biology, 2012. As a research scientist and writer with Dr. Grant Jensen at Caltech, she helped the lab develop and apply cryo-electron tomography imaging to structural cell biology. Pamela Bjrkman, Ph.D. Pamela Bjrkman, Ph.D., the David Baltimore Professor of Biology and Biological Engineering at the California Institute of Technology, will present the 34th annual Bertram M. Marx Lecture, hosted by the University of Alabama at Birmingham Department of Microbiology, Tuesday, March 1, from noon to 1 p.m. Bjrkman, a member of the prestigious National Academy of . The metalloprotein work defined the unusual structures of the nitrogenase FeMo-cofactor and the more widespread Mo-cofactor that .

Bio. At Guttman Lab, we aim to understand how noncoding RNAs shape dynamic nuclear structure to regulate gene expression. We strive to decipher basic . Assistant: Cheryl Nakashima. The editor-in-chief is Simon Harold. 1200 East California Boulevard . The Interdisciplinary Studies Program (ISP) enables students to craft custom-tailored curriculacomprising Caltech courses, academic-year research, courses at other schools, or independent study courses in collaboration with faculty advisors. Research. Major. The COVID-19 pandemic presents an urgent health crisis. Structural Mechanics; Interdisciplinary Studies Program. The research was done in the laboratory of Viviana Gradinaru (BS '05), assistant professor of biology . .

RIKEN Structural Biology Laboratory, Kanagawa 230-0045, Japan. California Institute of Technology. The journal was established in 2001 and is published by BioMed Central.

ImYoo launched with Caltech alumni CEO Tatyana Dobreva (PhD 2021) and CTO David Brown (PhD 2021) along with seed funding from the [email protected] and the Illumina Accelerator. The method is a breakthrough for testing new drugs to combat diseases like osteoporosis. RIKEN SPring-8 Center, Hyogo 679-5148, Japan. Current year files are for the 2021-2022 academic year. with particular emphasis on topics relevant to biology, energy, and the environment. Bil Clemons, PhD Professor of Biochemistry. The Chang lab in the University of Pennsylvania is deeply interested in understanding the basics of biology from a structural perspective. In the Gradinaru Lab, Xiaozhe is working on developing new molecular tools and viral vectors for neuroscience. Structural Biology @ Caltech Loading. In the Gradinaru Lab, Xiaozhe is working on developing new molecular tools and viral vectors for neuroscience. California Institute of Technology. The Interdisciplinary Studies Program (ISP) enables students to craft custom-tailored curriculacomprising Caltech courses, academic-year research, courses at other schools, or independent study courses in collaboration with faculty advisors. kbrodsky at caltech.edu. Xiaozhe received his BS from Tsinghua University, Bejing, China in 2014. and structural loading or expansion of vehicle performance envelopes during travel. Bil Clemons, PhD Professor of Biochemistry. Sarkis Mazmanian . Cellular Electron Cryotomography: Toward Structural Biology In Situ - CaltechAUTHORS Electron cryotomography (ECT) provides three-dimensional views of macromolecular complexes inside cells in a native frozen-hydrated state. Our most recent efforts combine directed evolution, simulation, and machine learning to optimize . Tweets by clemonslab 1200 E California Blvd. Understanding life at molecular level. The aim of this undergraduate program is to provide thorough training in the geological and planetary sciences and, wherever possible, to integrate these studies with courses in mathematics, physics, chemistry, and biology taken during the student's earlier years at the Institute. computational mechanics and structural dynamics to study natural ground surface features and man-made geotechnical systems --such as ridges, valleys, dams, tunnels, building foundations and offshore structures.

Wikimedia Commons has media related to Media from BMC Structural Biology Such structural meta-materials exhibit superior thermomechanical properties at extremely low mass densities (lighter than aerogels), making these solid foams ideal for many scientific and technological applications, especially in the medical field. Aaron Ames. . B.S., Pennsylvania State University, 1983; Ph.D., Caltech, 1987. . Director of the Caltech MEMS Lab MEMS, Bio-MEMS, Micromachining, lab-on-a-chip, microfluidics, drug delivery, micro implants, circulating tumor cell, parylene, Bio-med Matt Thomson Chemical Engineering Over the last two decades, ECT has revealed the ultrastructure of cells in unprecedented detail. . Facing a challenge akin to solving a 1,000-piece jigsaw puzzle while blindfoldedand without touching the piecesmany structural biochemists thought it would be impossible to determine the atomic structure of a massive cellular machine called the . Przemyslaw Dutka PhD student in the Jensen and Shapiro Labs @Caltech Structural Biology | Protein Engineering Greater Chicago Area 165 connections biology, engineering, medicine, and biophysicscreating a rich . In addition to imaging small cells, we have also made a major investment into the structural biology of the human immunodeficiency virus type 1 (HIV). Current Opinion in Structural Biology, 17 (4). The focus of the lab is the coupling of theoretical, computational, and experimental techniques for the study of structural biology. These three chemists and one physicist, all Nobel laureates, played a pivotal role in the creation of a new and pervasive branch of biology. This minor is intended to supplement one of Caltech's undergraduate degrees and is designed for students who wish to broaden their knowledge beyond their normal major, especially for those who wish to join the structural engineering profession after graduation or pursue a graduate degree in structural mechanics or structural engineering. BMC Structural Biology is an open access peer-reviewed scientific journal that covers research in structural biology. electrophysiology, and computer modeling, detailed structural . The chemistry program at Caltech provides depth in the traditional areas of chemistryorganic and inorganic chemistry, chemical physics, theoretical chemistry, and chemical biology. The video collection currently includes over 800 self-paced tutorials of varying duration (from 2 to over 98 hours). Bren Professor of Mechanical and Civil Engineering and Control and Dynamical Systems Professor Ames' research interests center on robotics, nonlinear control, hybrid systems and cyber-physical systems, with special emphasis on foundational theory and experimental realization on robotic systems; his lab designs, builds and tests novel bipedal robots and prosthesis with the goal of . Caltech Biochemist Sheds Light on Structure of Key Cellular 'Gatekeeper'. We believe that when science is inclusive, we can solve all problems. Caltech Biology & Biological Engineering Caltech Biology & Biological Engineering California Institute of Technology.